history of glp 1 agonists The expanding landscape GLP-1 medicines History of GLP-1: From Discovery

doi:10.1016/S0140-6736(20)30628-0 175

This understanding is in line with the chronotropic effects of GLP-1 RA treatment, which in a large meta-analysis was shown to be associated with heart rate increases of up to 3.35 beats/min (Sun et al., 2015)

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DCW, le Roux CW, Violante Ortiz R, Jensen CB, et al

Inclusion in the MDL does not establish that Trulicity caused any injury, but it reflects that plaintiffs are raising overlapping allegations across the GLP-1 drug category

16 Particularly the effects of these medications have covered importance in diseases closely related to obesity and DM such as CKD, cardiovascular disease and MASH

Diabetic Retinopathy Complications in Patients with a History of Diabetic Retinopathy: Rapid improvement of glucose control has been associated with temporary worsening of diabetic retinopathy