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Description
PDE5 inhibitors

Nausea, vomiting, and conditions like site reactions, headaches, and nasopharyngitis have been reported

It targets cognitive function directly, upregulating brain-derived neurotrophic factor and modulating dopamine and serotonin systems
Cerebrovascular outcome or events consisted of ischemic stroke (ischemia, ischemic stroke, vertebrobasilar insufficiency, cerebrovascular insufficiency, and lacunar infarction) or TIA (including reversible ischemic neurologic deficit), hemorrhagic stroke (hemorrhage and cerebral hematoma), and unspecified stroke (cerebrovascular accident, cerebrovascular disorder, hemiplegia, and hemiparesis)
This increases its duration of action, allowing for weekly injections

[DOI] [PubMed] [Google Scholar] 105.Acitores A., Gonzalez N., Sancho V., Valverde I., Villanueva-Penacarrillo M.L
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