glp-1 agonist cardiovascular outcomes Cardiovascular, mortality, and kidney with receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials Targeting the weight within: obesity
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Kenakin says this is always a hazard: If you have an oral drug, the organ that receives the highest dose is the liver 50% of all drugs fail on liver toxicity, he says

A market can show strong starts while long-term continuation remains fragile
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N Engl J Med 384(12):11131124 Osaka T, Endo M, Yamakawa M, Inoue S (2005) Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system

This will be a huge field, Moore
Physiology and Behavior

95% CI, 0.96-3.85, respectively)