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The FDA established enforcement discretion periods for compounding pharmacies - with various deadlines through mid-2025 - after which compounders could generally no longer rely on the shortage exception to produce "essentially a copy" of these FDA-approved drugs

When these two mechanisms work together, the results exceed what either could achieve alone

Portion sizes naturally shrink

Side effects are typically manageable by this phase because your body has been adapting for 12+ weeks

Jastreboff AM, Kaplan LM, Fras JP, et al

The best time to make this switch is at the beginning of a new vial, so you do not waste medication from a partially used vial of the non-B6 formulation