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5 Persistence and discontinuation Persistence with GLP-1 therapy has been a major concern

Coverage varies depending on your insurance plan

Sublingual delivery bypasses first-pass liver metabolism, potentially improving bioavailability compared to swallowed oral forms, though it still does not match injectable absorption rates

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Who likely does not need it: People eating varied, nutrient-dense diets and taking multivitamins without symptoms of deficiency

Studies show that two-thirds of weight lost on GLP-1 medications is typically regained within 12 months of stopping treatment, with cardiometabolic benefits often reversing as well 2*