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J Clin Neurol 2006

The alterations that occur in this signal transduction pathway may have genetic and/or epigenetic origins

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Dose escalation happens gradually over the following weeks under clinician guidance

Sitagliptin Add-on Therapy in Patients with Type 2 Diabetes Inadequately Controlled on Metformin Alone A total of 701 patients with type 2 diabetes participated in a 24-week, randomized, double-blind, placebo-controlled study designed to assess the efficacy of sitagliptin in combination with metformin