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Description
A 2019 randomized, placebo-controlled study in Nutrients, the first human clinical study on the ingredient, evaluated potential impacts on subjective ratings of appetite during a 24-hour water-only intermittent fast

Only four saw a slight regain, with the largest increase being 8 lbs

Metabolic health stayed stable
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At the end of the experiment, rats were euthanized by an overdose of pentobarbital (150 mg/kg, i.p.)

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