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Second, they may work by modulating the immune response and reducing levels of proinflammatory cytokines involved in HS pathogenesis. Evidence also points to GLP-1 receptor agonists decreasing inflammatory markers such as erythrocyte sedimentation rate a finding that suggests a broader anti-inflammatory effect, according to the researchers

doi: 10.1002/jcp.25033

Managing the Transition Period After Stopping Gradual dose reduction rather than abrupt discontinuation may help reduce rebound GI symptoms in some patients, though clinical guidance on tapering is still evolving

Patients with T2D generally experience fewer GI side effects

"Whilst human studies demonstrating an impact on cognitive decline are still lacking, the current evidence points towards these drugs having a preventative effect, rather than in patients with established cognitive impairment," says Cork