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Hormone-sensitive lipase, activated by glucagon and other signals, breaks down triglycerides stored in adipocytes (fat cells) into glycerol and free fatty acids
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NICE guidance on tirzepatide emphasizes the importance of clinical oversight during these adjustments to ensure patient safety and long-term success
Preclinical studies have shown that balanced activation of these receptors avoids the hyperglycemic risk associated with glucagon monotherapy while preserving its lipolytic benefits [19]
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