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This interaction may occur through two mechanisms: First, GLP-1 RA may decrease sodium reabsorption in the proximal tubule, leading to increased delivery of sodium chloride to the macula densa and subsequent activation of the tubuloglomerular feedback mechanism, which inhibits renin secretion [57]

And if you're taking Ozempic "off-label" for weight loss, you should be aware that the side effects, including constipation, are the same regardless of why you're taking it

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10.1002/pst.397 [DOI] [PubMed] [Google Scholar] 17

Interestingly, the study did not find a statistically significant association between GLP-1 agonist use and hospitalization due to suicide attempts