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Only eight of the included studies examined newer GLP-1 medications, and none followed participants for more than 12 months after stopping treatment

Increased Energy Expenditure: GLP-1 RAs may activate sympathetic pathways in the hypothalamus (specifically the dorsomedial and ventromedial nuclei) that increase thermogenic activity in brown adipose tissue (BAT), contributing to increased energy expenditure and weight loss

Called liraglutide, the company began clinical testing of the drug for diabetes in 1997

It facilitated the clearance of the accumulated intermediates from both - and -oxidation

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