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PMCID: PMC7919569

It may be most appropriate in older patients or those with multiple areas requiring significant volumization

If you feel "too full" to eat or experience food aversion, we have likely passed your sweet spot

If you have been on an adequate dose for 8-12 weeks with confirmed proper technique, storage, and supportive lifestyle factors, and you are still seeing no response whatsoever, you may be a non-responder to this particular medication

It is tempting to speculate that treatment of GLP-1 RAs might be combined with drugs targeting calcium clock dynamics or intracellular calcium levels, such as calcium channel blockers, or other downstream effectors, to prevent heart rate increases in patients receiving GLP-1 RAs where this may be considered beneficial

Some studies have shown value of initial metformin-DPP-4 inhibitor combination therapy in special populations