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While paraxanthine delivers most of caffeine's beneficial effects with a relatively short half-life of 3.1 hours, the other two metabolites are more problematic
Subsequent studies demonstrated that apelin signaling is highly context dependent, with differential coupling to G_i, G_q, and -arrestin pathways depending on ligand structure, receptor density, and tissue environment (Murali and Aradhyam, 2023)
The condition, also known as Severs disease, usually occurs in children during growth spurts
