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However, GLP-1 agonists were not associated with an increased risk for biliary disease (HR = 1.5

Doses of both Wegovy and Zepbound can be purchased directly from the pharmaceutical companies at $499 a month, with Zepbounds starter dose of 2.5 mg costing $349 a month

If the program proves that coverage results in cost savings for CMS and improved health outcomes, that could put pressure on more private insurers and employers to cover GLP-1s for obesity on commercial plans, he added

But theyre not meant to be a long-term solution when FDA-approved options are available

Since branded semaglutide and tirzepatide are now fully available, prescribers are expected to document that the compounded version serves a specific individualized medical need that the branded version cannot

Guidelines are evolving, formularies are shifting, and patient expectations are rising
