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Description
The remaining 1% consists of other peptide-related impurities, typically truncated sequences, deletion sequences, or oxidized forms of the target peptide

Another study used NCI-H716 cells and ERK1/2 inhibitors to investigate how Sennoside A (SA) induces GLP-1 synthesis

doi: 10.1056/NEJMoa1916038 [DOI] [PubMed] [Google Scholar] 98

While these side effects typically improve over time as your body adjusts, there are several ways to ease nausea more quickly

SURPASS-2 Investigators
Whether that balance holds in bigger, more varied groups of people is exactly what the Phase 3 TRIUMPH trials are out to test
