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Keywords: GIP-1, GLP-1RAs, liraglutide, obesity, semaglutide, tirzepatide 1

Gut 67 , 672678 (2018)

So, our statins, which it seems like everybody over 60 takes today to treat high cholesterol

Naunyn Schmiedebergs ArchPharmacol

Protocol 1: the slow and steady semaglutide escalation Goal: Minimize side effects while reaching effective therapeutic levels Schedule: Weeks 1-6: 0.25 mg weekly (extended from standard 4 weeks) Weeks 7-12: 0.5 mg weekly (extended) Weeks 13-16: 1.0 mg weekly Weeks 17-20: 1.7 mg weekly Week 21+: 2.4 mg maintenance Why the plotter supports this: By extending the initial low-dose phases to six weeks instead of four, you ensure complete steady state establishment before escalation

The cardinal rule is the calendar bends to the gut, not the other way around
