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Why Some Patients Gain Weight on Tirzepatide Therapy Weight gain on GLP-1 receptor agonists and dual GIP/GLP-1 agents like tirzepatide typically stems from five mechanisms: inadequate dosing for your metabolic phenotype, insufficient time to reach therapeutic dose, lifestyle factors offsetting medication benefits, hormonal imbalances unrelated to the peptide pathway, and individual genetic variation in how your body processes these compounds

Optimise nutritional intake by ensuring adequate protein (approximately 0.75g per kilogram body weight daily), iron-rich foods, and varied nutrient-dense meals despite reduced appetite

The key insight is that semaglutide does not target one system in isolation

Wegovy is similar to Ozempic which is also a brand of semaglutide

Potential Drawbacks of Weight Loss Supplements According to NIHs Office of Dietary Supplements, there is limited evidence supporting the effectiveness of weight loss supplements