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It is thought to promote weight loss through various mechanisms, including effects on the central nervous system, metabolic changes, and suppressing appetite
Proctor et al., 2008), indicating reliance on specific transporter proteins for its uptake

As off-label use of GLP-1 agonists continues to rise, particularly for weight loss in otherwise healthy individuals, the authors cite the need for additional guidelines and research

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They found that even when weight loss was completely removed from the equation, semaglutide still reduced liver fat, inflammation, and fibrosis
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