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A common simple protocol used in laboratory studies starts with 0.5 mg of Tirzepatide once per week, administered subcutaneously. The dose is then titrated upward by 0.51 mg every 4 weeks until the individual researcher reaches a comfortable maintenance level. Maintenance dosing is subjective and based on personal response and tolerance

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Conclusions/interpretation Our findings do not support an increased risk of SIS when taking GLP-1RA in individuals with type 2 diabetes and obesity