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Since the glucose-lowering effects of GIP have been shown to be impaired in patients with T2D, interest has focused on developing antidiabetic therapies based upon the actions of GLP-1 and GIP, the response to which remains intact. To continue reading Log in or register to continue reading

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Mechanistic analyses from the SUMMIT trial [165] demonstrated that, compared with placebo, tirzepatide reduced blood pressure and attenuated circulatory volume expansion in obese HFpEF patients

When to discuss a dose increase If you have been at your current dose for four or more weeks with minimal appetite suppression or weight change, a dose increase is usually the appropriate next step