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When someone applies for life insurance after losing weight on GLP-1 medications, underwriters see what looks like a healthy person with: Normal BMI Improved blood pressure Better cholesterol levels Lower HbA1c levels But here's the catch: Research from the landmark STEP 1 trial extension shows that participants regain approximately two-thirds of their prior weight loss within one year of stopping semaglutide (Wilding et al., 2022)

Furthermore, an in vivo evaluation of a PA-GLP1/dPA hydrogel formulation in a type 2 diabetic rat model demonstrates similar therapeutic effects to daily semaglutide injections by reducing blood glucose levels and mitigating weight gain [209] ( Fig

These were typically temporary and disappeared as the body acclimated

it requires proper diet and regular physical activity
Rotating injection sites helps prevent irritation
