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Historical Background and Scientific Context Scientific research into incretin hormones expanded significantly during the late twentieth century as advances in molecular biology enabled detailed investigation of endocrine metabolic systems
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Given the observed increased risk of colorectal cancer among patients receiving GLP-1 receptor agonists, clinicians should approach long-term prescribing of these agents with careful consideration, particularly in individuals with additional risk factors for colorectal cancer, such as a family history, obesity, inflammatory bowel disease, or long-standing type 2 diabetes
Semaglutide is a synthetic GLP-1 (glucagon-like peptide-1) that mimics a protein made in the intestine that stabilizes blood sugar and insulin levels

Applying a Personalised, Clinic-led Approach With The Health Suite Deciding whether HBOT is appropriate requires individualised assessment
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It can also be a challenge to eat normally
