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Although much of the hair loss being reported after starting GLP-1 medications could be temporary telogen effluvium related to rapid weight loss or nutritional stress, he believes it is entirely plausible that in those genetically predisposed to androgenetic alopecia, [GLP-1s] may be triggering its early onset. Nusbaum, of the Miami Hair Institute, said he has started to see several patients with underlying androgenetic alopecia, which is male- or female-pattern hair loss, where that underlying condition is being exacerbated by the use of these medications. Androgenetic alopecia has a distinct pattern
GLP-1 and GIP receptors can form dimers, which then increases the amount of cAMP produced and, furthermore, can change the second messenger cascade to a PLC-IP3-PiP3-Alt/PKB cascade [103, 104] (Fig

This clinical evidence base has legitimized GLP-1 compounds as mainstream precision medicine rather than niche diabetes treatment

DemarkWahnefried W., Campbell K

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