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(4) PEGylation

Swelling is minimal and stays localized

Common side effects reported with GLP-1 medications include nausea which is often most pronounced during dose escalation, vomiting, diarrhea, constipation, abdominal discomfort, and decreased appetite which is also part of how the medication works

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Post-surgical or scarred areas Surgical scars, C-section scars, liposuction areas, and significant burn scars all alter the subcutaneous tissue structure

Interpreting the Evidence Much like with the Antagonistic hallmarks, current evidence in improvements of Integrative Hallmarks are strongest in populations with metabolic dysfunction, particularly type 2 diabetes