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In a new review from top dietitians in Australia, it appears very few global trials of GLP-1s have taken into consideration what and how much patients are eating while using them leading to serio

GLP-1 receptor agonists show potential anti-inflammatory mechanisms, but evidence for rheumatoid arthritis benefit remains limited

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Exceedingly short half-life (12 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question
Medicare is not allowed by law to cover drugs for chronic weight management, although Congress is facing pressure to change that.
