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Gastrointestinal side effects are the most common including nausea, vomiting, and diarrhea

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For the TRIUMPH trials (TRIUMPH-4, TRIUMPH-1, TRANSCEND-T2D-1): alcohol consumption was not a tracked variable, and the trials provide no direct data on alcohol interactions

Regarding newer agents, evidence from phase 2 trials indicates that the triple agonist retatrutide (GLP-1R/GIPR/GCGR) can achieve unprecedented weight loss of up to 24.4% (Jastreboff et al., 2023)

Health history and medications are reviewed carefully before treatment begins

Ali also points out that more research is needed