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Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks

Zhou H, Ji L, Song X et al (2024) ZT002, a novel ultra long-acting GLP-1 receptor agonist in adults with overweight or obesity: a randomised, placebo-controlled, multiple ascending dose phase 1c study

Similarly, spironolactone can slow androgen-related scalp hair loss, with modest improvements typically appearing within the same timeframe

Eating smaller, more frequent meals reduces nausea

Rybelsus is the first and only oral GLP-1 RA approved for the treatment of type 2 diabetes, following its launch in 2019

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