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Since ESSENCE was designed to evaluate semaglutide in participants with underlying liver disease, hepatic function tests were measured every 12 weeks, and criteria were established for discontinuation in participants with an increase in pre-specified changes in ALT, AST, total bilirubin, or INR (Supplemental Table S1, Among the 538 participants receiving semaglutide, none stopped it because of elevated ALT or AST

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Results suggest a potential effect of glutamine on oxidative stress and inflammatory markers

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