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Ralph DeFronzo proposes treating diabetes with combination drug therapy rather than single medications

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Backed by more than five years of real-world clinical data, Calibrate members achieve an average of 18% weight loss at one year and sustain these results over the long term, far exceeding outcomes from medication alone

Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology

A simplified graphic demonstrating the differences between endogenous and exogenous GLP-1