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The experiments were initiated with the sequential addition of substrates: 0.5 mM malate, 5 mM pyruvate, 5 mM glutamate, and 10 mM succinate

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Its main modification is a C16 palmitoyl moiety covalently attached to the lysine at position 20 through a -glutamic acid chemical spacer

During those early clinical trials, doctors began to notice a pattern they hadnt planned for patients werent just getting better blood sugar control

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