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Because of the GI effects, caution is advised in patients with severe gastroparesis (e.g., long-standing diabetic gastroparesis) GLP-1 RAs can worsen gastric emptying delays and are generally not recommended in that scenario

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Research has found that approximately 40% of the weight lost from taking semaglutide comes from lean mass, including muscle

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These processes are thought to be associated with the increased muscular SOCS3 and PTP1B and the weakened JAK2-STAT3, AMPK, IGF-1 and GLUT4 signaling [226, 229], [230], [231], [232]

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