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Vagus nerve stimulation reduces body weight and fat mass in rats

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12 Furthermore, GLP-1RAs reduce the secretion of proinflammatory cytokines, namely interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-), which are often elevated in neuroinflammatory conditions like migraine

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7c, e, f)

In fact, GIPR desensitization appears so severe that antagonism of this receptor phenocopies its agonism [42,51]