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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.de Brito Toscano EC, Vieira L, Dias BB, Caliari MV, Gonalves AP, Giannetti AV, Siqueira JM, Suemoto CK, Leite RE, Nitrini R, et al

GIP works alongside GLP-1 but acts through a separate receptor research suggests it may amplify GLP-1's appetite-suppressing effects and independently influence how the body stores and uses fat

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It is a two-part trial where 1,197 participants were randomized 2:1 to receive semaglutide 2.4 mg or placebo, on top of standard of care for 240 weeks