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Several theoretical mechanisms may explain this phenomenon

Discussion The three trials summarized in TABLE 2 provide consistent evidence that GLP-1 RAs may be an advantageous alternative to prandial insulin as add-on therapy to basal insulin

Reason for caution: GLP-1 receptors are present in thyroid C-cells

[DOI] [PubMed] [Google Scholar] 43.Mulvihill E.E

Much of the data showed people stopped taking these drugs due to negative side effects like bloating, nausea and stomach pain

Future studies will need prospective designs or randomized trials to validate these findings and better understand the mechanisms linking metabolic interventions with CRS outcomes, Chaaban said