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Clinical Evidence for Dual Therapy With GLP-1 Agonists Multiple randomized controlled trials have evaluated GLP-1 agonists and tirzepatide in patients already stabilized on metformin

4 Further to this, metabolic disorders, for example diabetes and obesity, have been shown to negatively alter the bone microenvironment and compromise bone quality

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however, according to Stanford Medicines blog Scope, its a warning sign if the changes are fast, but if they happen gradually, theres nothing to worry about