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We are seeing more options, new mechanisms, and levels of efficacy that were unimaginable just a few years ago, including oral therapies and medications approaching weight loss previously seen only with surgery

The findings add to the growing conversation around drug repurposing where existing medications reveal unexpected benefits

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Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist increasingly prescribed for weight loss, is generally well tolerated but may have underrecognized gastrointestinal complications

RMR, carbohydrate oxidation and gastric emptying rate were lower during the GLP-1 infusion compared with the saline infusion (P<0.001, P<0.05, P<0.0001, respectively)

The STEP UP T2D trial showed that weekly semaglutide 7.2 mg led to a 13.2% weight loss vs 3.9% with placebo in adults with obesity and T2D