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Appetite changes often appear within days to two weeks, whilst blood glucose improvements typically emerge within 24 weeks

This alters the intended pharmacokinetics and may increase the risk of adverse effects

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Studies were excluded if they met at least one of the following exclusion criteria: (1) non-primary research (e.g., review articles, commentaries, letters to the editor, dissertations, protocols, published abstracts), (2) case reports or case series, (3) does not use a GLP-1 receptor agonist as an intervention, and (4) does not report on glutamatergic or NMDA/AMPA receptor activity

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