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In a large study of over 18,000 patients, those taking tirzepatide lost about 15.3 percent of body weight in one year compared to 8.3 percent with semaglutide

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6 8 This methodological point becomes important later: a drug that lowers fasting insulin and HOMA-IR chiefly by unloading liver fat may be improving the hepatic component of insulin resistance more than the muscle component, and only clamp-based studies none of which exist for retatrutide in PCOS could disentangle the two

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