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In addition to that, DPP-4 enzyme also deactivates more than 40 physiologically active hormones, neuropeptides, cytokines, and other proteins in vivo through dipeptide cleavage (Mentlein et al., 1993)

In the ongoing SURPASS-CVOT trial (ClinicalTrials.gov ID NCT04255433), the safety of tirzepatide versus GLP-1RA dulaglutide is assessed in patients living with T2DM with confirmed atherosclerotic CVD, including participants treated with insulin and SGLT2 inhibitors, where the composite primary outcome will be the time to first occurrence of MACE

If you do use them, use them for a short period of time

We know that patients taking GLP-1 RAs have an increased incidence of residual gastric contents even when fasting

Emerging combinatorial hormone therapies for the treatment of obesity and T2DM

In your clinical experience, which adverse effect of sulfonylureas do you encounter most frequently