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In October, a compounding industry group, the Outsourcing Facility Association, filed a lawsuit against the FDA's decision that there was no longer a shortage of tirzepatide, the active ingredient fin Zepbound and Mounjaro

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doi: 10.23876/j.krcp.22.001 56 AstrupACarraroRFinerNHarperAKunesovaMLeanMEet al

l-Arginine, a potent insulin secretagogue [309], also stimulates GLP-1 release from isolated rat intestine, and, when given orally, augments GLP-1 and insulin levels and improves glucose tolerance in mice, effects that are absent in GLP-1R KO mice [305]

Major weight loss most likely will not occur in the first week of treatment with a GLP-1

At the same time, prescribing trends shifted, with AOM semaglutide experiencing its largest monthly increase while AOM tirzepatide growth slowed and initiations declined
