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In STEP 1 and SURMOUNT-1, semaglutide and tirzepatide produced large, durable reductions in body weight, setting a new efficacy benchmark for pharmacotherapy [1,2]

Your body also develops what researchers call 'metabolic adaptation'a biological drive to restore previous body weight through increased hunger and reduced energy expenditure

If youre struggling to manage your constipation or experience severe or persistent symptoms, its wise to talk with your doctor
Ensure you pack sufficient medication to cover your entire trip plus extra in case of delays or unexpected itinerary changes

Semaglutides off-patent entry could also reshape treatment landscapes in adjacent cardio-metabolic areas like heart failure, stroke and kidney disease
