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Hypocaloric diets, when not adjusted for protein density, increase the risk of disproportionate lean mass loss [41]

In individuals with AD, GLP-1RAs did not exert disease-modifying effects on cognition

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Although there was no significant improvement in glycaemia with efinopegdutide, this was explicable given that the participants had normal glycaemia at baseline

These findings underscore the varying psychiatric risks associated with different GLP-1 RAs and the importance of individualized patient assessment in clinical practice