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Medullary Thyroid Carcinoma (MTC) risk Like GLP-1 medications, retatrutide also has a black box warning for medullary thyroid carcinoma and MEN 2 syndrome

These patients are a minority in the trial data, but they exist

If possible, GLP-1 RAs should not be used during pregnancy because of observed reproductive toxicity in animals

Ultimately, these effects promote neocollagenesis and soft tissue remodeling [36]

That's roughly 50 times less than the research doses

But it does mean your food choices, meal timing, hydration, and symptom plan may need to be adjusted
