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Both dietary approaches, when integrated with semaglutide therapy, have the potential to preserve lean body mass, reduce gastrointestinal adverse events, and enhance adherence through improved satiety and tolerability

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Evidence-based guidance for UK patients taking semaglutide or liraglutide.

Among patients with obesity, semaglutide 7.2 mg reduced body weight by more than 18% for those without diabetes and by more than 13% for those with diabetes, according to the results of the STEP UP and STEP UP T2D trials
However, owing to their peptide-based composition, GLP-1RAs have traditionally required injectable administration, which undermines patient adherence, convenience, and long-term accessibility
