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Cochrane-standard systematic reviews have examined the randomized controlled trial data across multiple GLP-1 medications, and the weight of the published evidence supports the conclusion that in properly selected patients, GLP-1 receptor agonists produce clinically meaningful weight loss that exceeds what diet and exercise alone typically achieve without pharmacological support

Clinicians have raised alarms about this shift

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We spoke to a series of doctors to find out whether natural GLP-1s are worth trying

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