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In a study of 18 people with AD, exenatide treatment for 18 months was associated with lower plasma-sourced, neuron-derived extracellular vesicle (NDEV) A42 levels, although all other fluid biomarkers remained unchanged (62)

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34 , 35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36 , 37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38 , 39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals
Effects of Semaglutide on Chronic Kidney Disease in Patients With Type 2 Diabetes

Investigating local administration through phase 1 safety and pharmacokinetic trials is a critical first step to bypass the BRB and maximize retinal tissue exposure while minimizing systemic side effects
