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Description
They are grounded in endogenous biology, often supported by convergent evidence across species and experimental modalities, and frequently act at integrative nodes that coordinate multiple physiological processes
Thyroid function, iron levels, and vitamin D status should all be evaluated
This multi-pronged approach is distinct from earlier-generation peptides that typically target one or two of these pathways
Same general shape
ECC5004/AZD5004 (AstraZeneca/Eccogene) and several Chinese programs are not far behind (see, e.g., here and here)
doi:10.1124/jpet.123.001733
