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What the evidence says GLP-1 receptor agonists and RA disease activity A 2025 study by Kellner and colleagues in ACR Open Rheumatology examined 173 RA patients with a BMI of 27 or higher who were prescribed a GLP-1 receptor agonist (semaglutide or tirzepatide), compared with 42 controls

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Serotonin is produced by specific neurons localized in raphe nuclei in the brainstem (Llewellyn-Smith et al., 2013)