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These effects likely stem from GLP-1s action on brain receptors involved in reward processing

This could help explain individual differences among humans in responsiveness to these drugs, including some well-known sex differences

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Additional information Journal peer review information : Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

And then more specifically as we see additional conditions that are responsive to the treatment of obesity, while that too may challenge our sponsors, it really allows us to potentially over the long haul deliver reductions in total cost of care, perhaps offset by the cost of the agent, but by reducing hospital utilization, ER utilization, transplantation, durable medical equipment, and a variety of complications of obesity