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PIONEER 4: Head-to-head vs liraglutide 1.8 mg 11 Study design: 52-week, randomized, double-blind, double-dummy, active controlled, and placebo-controlled phase 3a trial designed to assess the safety and efficacy of semaglutide tablets vs subcutaneously injected GLP-1 RA, liraglutide

Numerous large randomized controlled trials have reported statistically significant reductions in CV events for three of the FDA-approved SGLT2 inhibitors (empagliflozin, canagliflozin, and dapagliflozin) and four FDA-approved GLP-1 receptor agonists (liraglutide, albiglutide [although that agent was removed from the market for business reasons], semaglutide [lower risk of CV events in a moderate-sized clinical trial but one not powered as a CVOT], and dulaglutide)

Intracellular endothelial cell metabolism in vascular function and dysfunction

Type 2 diabetes and insulin: dont be scared, heres what you need to know : Think you might be ready for insulin
D., Lachmann T., Jaarsveld S., Riedel-Heller S
